Biomarker validation is still the bottleneck in biomarker research
نویسندگان
چکیده
منابع مشابه
Neopterin: still a forgotten biomarker.
To the Editor: We read with interest the recent authoritative review article by Apple et al. (1) regarding biomarkers and acute coronary syndromes (ACS). Although the article is both exhaustive and clinically relevant, we felt that the authors failed to recognize the potential value of neopterin as a marker of cardiovascular risk. Neopterin, a pteridine derivative produced by activated macropha...
متن کاملBreaking the bottleneck in the protein biomarker pipeline.
The process for discovery and development of biomarkers of solid tumors presents exceptional challenges. The major technical obstacle is the disconnection between the site of their generation (tissue, proximal fluid) and the source of detection (body fluids, predominantly serum and plasma). This single factor limits, in practical terms, the potential pool of biomarkers to those that are secrete...
متن کاملBiomarker discovery and validation.
Currently available biomarkers, such as those used to diagnose myocardial infarction (e.g., cardiac troponins), were identified in the course of targeted physiologic studies. Similarly, basic investigation of diseases has largely been characterized by studies of isolated molecules in cellular systems. Advances in genomics technologies, however, are beginning to permit characterization of global...
متن کاملAnalytical Performance of ELISA Assays in Urine: One More Bottleneck towards Biomarker Validation and Clinical Implementation
ELISA is the main approach for the sensitive quantification of protein biomarkers in body fluids and is currently employed in clinical laboratories for the measurement of clinical markers. As such, it also constitutes the main methodological approach for biomarker validation and further qualification. For the latter, specific assay performance requirements have to be met, as described in respec...
متن کاملApplying biomarker research.
Public health and environmental professionals have generally focused on monitoring the ambient environment to assess exposures to the public. To understand exposures and effects and predict onset or course of disease, it is also important to look inside the (human) organism. Biomarkers—measurable internal indicators of changes in organisms at the molecular or cellular level—offer great potentia...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Internal Medicine
سال: 2012
ISSN: 0954-6820
DOI: 10.1111/j.1365-2796.2012.02579.x